Drug interactions
Chloroquine + Paroxetine
Severity: Minor
Chloroquine and Paroxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloroquine inhibits CYP2D6 and may modestly increase paroxetine levels, although paroxetine's own saturable CYP2D6 metabolism and strong inhibition limit the effect. Higher exposure could increase adverse effects such as nausea or sedation.
What this interaction means in plain words
Chloroquine and Paroxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chloroquine belongs to Anti Parasitic; Paroxetine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by chloroquine reduces paroxetine metabolism.
What to do
Monitor for paroxetine adverse effects and adjust the dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Chloroquine with Paroxetine?
MediHelp rates the interaction as minor. Chloroquine and Paroxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chloroquine inhibits CYP2D6 and may modestly increase paroxetine levels, although paroxetine's own saturable CYP2D6 metabolism and strong inhibition limit the effect. Higher exposure could increase adverse effects such as nausea or sedation.
How serious is the interaction between Chloroquine and Paroxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for paroxetine adverse effects and adjust the dose if needed.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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