Drug interactions
Chloroquine + Propranolol
Severity: Moderate
Chloroquine and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloroquine may increase propranolol exposure by inhibiting CYP2D6, which contributes to its metabolism. This can enhance bradycardia and hypotension.
What this interaction means in plain words
Chloroquine and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloroquine belongs to Anti Parasitic; Propranolol belongs to Cardiovascular.
Why it happens
Chloroquine inhibits CYP2D6-mediated propranolol metabolism.
What to do
Monitor heart rate and blood pressure and reduce the propranolol dose if excess beta-blockade develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Chloroquine with Propranolol?
MediHelp rates the interaction as moderate. Chloroquine and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloroquine may increase propranolol exposure by inhibiting CYP2D6, which contributes to its metabolism. This can enhance bradycardia and hypotension.
How serious is the interaction between Chloroquine and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and reduce the propranolol dose if excess beta-blockade develops.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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