Drug interactions
Chloroquine + Tolterodine
Severity: Moderate
Chloroquine and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloroquine can inhibit CYP2D6 and may raise tolterodine levels. Both drugs can prolong the QT interval, so combined use may increase arrhythmia risk.
What this interaction means in plain words
Chloroquine and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloroquine belongs to Anti Parasitic; Tolterodine belongs to Genitourinary.
Why it happens
Chloroquine inhibits CYP2D6, and both drugs have additive QT-prolonging effects.
What to do
Check baseline ECG and electrolytes, and monitor QTc during co-administration. Consider an alternative to tolterodine if QT risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Frequently asked questions
Can I take Chloroquine with Tolterodine?
MediHelp rates the interaction as moderate. Chloroquine and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloroquine can inhibit CYP2D6 and may raise tolterodine levels. Both drugs can prolong the QT interval, so combined use may increase arrhythmia risk.
How serious is the interaction between Chloroquine and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes, and monitor QTc during co-administration. Consider an alternative to tolterodine if QT risk is high.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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