Drug interactions
Chlorothiazide + Esmolol
Severity: Minor
Chlorothiazide and Esmolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, so hypotension may be additive, especially with intravenous chlorothiazide in volume-depleted patients. Thiazide-induced hypokalemia can add to arrhythmia risk.
What this interaction means in plain words
Chlorothiazide and Esmolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorothiazide belongs to Cardiovascular; Esmolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic blood pressure lowering plus thiazide-induced potassium loss.
What to do
Monitor blood pressure during esmolol titration and check serum potassium, replacing it as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Esmolol?
MediHelp rates the interaction as minor. Chlorothiazide and Esmolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs lower blood pressure, so hypotension may be additive, especially with intravenous chlorothiazide in volume-depleted patients. Thiazide-induced hypokalemia can add to arrhythmia risk.
How serious is the interaction between Chlorothiazide and Esmolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during esmolol titration and check serum potassium, replacing it as needed.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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