Drug interactions
Chlorothiazide + Indacaterol-glycopyrronium
Severity: Moderate
Chlorothiazide and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics lower serum potassium, and beta2-agonists can transiently lower it further by shifting potassium into cells. Combined hypokalemia can promote cardiac arrhythmias, especially at higher doses or in patients with heart disease.
What this interaction means in plain words
Chlorothiazide and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Additive hypokalemia through renal potassium loss and beta2-mediated intracellular shift.
What to do
Monitor serum potassium and magnesium, particularly at treatment start and with dose changes. Supplement potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Chlorothiazide and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics lower serum potassium, and beta2-agonists can transiently lower it further by shifting potassium into cells. Combined hypokalemia can promote cardiac arrhythmias, especially at higher doses or in patients with heart disease.
How serious is the interaction between Chlorothiazide and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium, particularly at treatment start and with dose changes. Supplement potassium as needed.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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