Drug interactions
Chlorothiazide + Labetalol
Severity: Minor
Chlorothiazide and Labetalol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics are often combined with beta-blockers and their blood-pressure-lowering effects are additive. Thiazides may cause hypokalemia and impaired glucose tolerance, and beta-blockers can mask hypoglycemia symptoms in diabetic patients.
What this interaction means in plain words
Chlorothiazide and Labetalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorothiazide belongs to Cardiovascular; Labetalol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects; thiazide-induced electrolyte and glucose changes.
What to do
Monitor blood pressure, potassium and glucose, especially in diabetic patients. No dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Labetalol?
MediHelp rates the interaction as minor. Chlorothiazide and Labetalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics are often combined with beta-blockers and their blood-pressure-lowering effects are additive. Thiazides may cause hypokalemia and impaired glucose tolerance, and beta-blockers can mask hypoglycemia symptoms in diabetic patients.
How serious is the interaction between Chlorothiazide and Labetalol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, potassium and glucose, especially in diabetic patients. No dose change is usually needed.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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