Drug interactions
Chlorothiazide + Lurasidone
Severity: Moderate
Chlorothiazide and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone can cause orthostatic hypotension, and thiazide diuretics lower blood pressure through volume depletion. Together, hypotension and dizziness may be more pronounced, especially in older or volume-depleted patients.
What this interaction means in plain words
Chlorothiazide and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Lurasidone belongs to Central Nervous System.
Why it happens
Additive hypotensive effects of alpha-1 adrenergic blockade and diuretic-induced volume reduction.
What to do
Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug. Reduce the diuretic dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Lurasidone?
MediHelp rates the interaction as moderate. Chlorothiazide and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone can cause orthostatic hypotension, and thiazide diuretics lower blood pressure through volume depletion. Together, hypotension and dizziness may be more pronounced, especially in older or volume-depleted patients.
How serious is the interaction between Chlorothiazide and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug. Reduce the diuretic dose if symptomatic hypotension occurs.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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