Drug interactions
Chlorothiazide + Magnesium hydroxide
Severity: Minor
Chlorothiazide and Magnesium hydroxide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorothiazide can raise urinary magnesium loss and cause hypomagnesemia, particularly with prolonged use. Magnesium antacids may modestly offset this.
What this interaction means in plain words
Chlorothiazide and Magnesium hydroxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorothiazide belongs to Cardiovascular; Magnesium hydroxide belongs to Gastrointestinal Tract.
Why it happens
Thiazide diuretics increase renal magnesium excretion.
What to do
Monitor serum magnesium during prolonged therapy and supplement if low.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Magnesium hydroxide
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Magnesium hydroxide?
MediHelp rates the interaction as minor. Chlorothiazide and Magnesium hydroxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chlorothiazide can raise urinary magnesium loss and cause hypomagnesemia, particularly with prolonged use. Magnesium antacids may modestly offset this.
How serious is the interaction between Chlorothiazide and Magnesium hydroxide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium during prolonged therapy and supplement if low.
What other medicines interact with Magnesium hydroxide?
MediHelp also lists interactions of Magnesium hydroxide with, for example, Ciprofloxacin, Dolutegravir, Gemifloxacin. The full list is on the Magnesium hydroxide page.
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