Drug interactions
Chlorothiazide + Metoprolol
Severity: Minor
Chlorothiazide and Metoprolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics and beta-blockers are commonly combined for hypertension and give additive blood pressure lowering. Thiazides can cause hypokalemia, hyperglycemia and dyslipidemia, and beta-blockers may mask hypoglycemia symptoms and worsen glucose control, so metabolic effects may be additive.
What this interaction means in plain words
Chlorothiazide and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorothiazide belongs to Cardiovascular; Metoprolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive pharmacodynamic effects, with overlapping adverse metabolic effects on glucose and lipids.
What to do
Monitor blood pressure, serum potassium and glucose periodically, particularly in diabetic patients. Correct hypokalemia and adjust doses as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Metoprolol?
MediHelp rates the interaction as minor. Chlorothiazide and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics and beta-blockers are commonly combined for hypertension and give additive blood pressure lowering. Thiazides can cause hypokalemia, hyperglycemia and dyslipidemia, and beta-blockers may mask hypoglycemia symptoms and worsen glucose control, so metabolic effects may be additive.
How serious is the interaction between Chlorothiazide and Metoprolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium and glucose periodically, particularly in diabetic patients. Correct hypokalemia and adjust doses as needed.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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