Drug interactions
Chlorothiazide + Rosiglitazone
Severity: Minor
Chlorothiazide and Rosiglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and impair glucose tolerance, which may reduce the effectiveness of rosiglitazone. The effect is generally modest and dose related.
What this interaction means in plain words
Chlorothiazide and Rosiglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorothiazide belongs to Cardiovascular; Rosiglitazone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: thiazides reduce insulin secretion and sensitivity, partly via hypokalemia.
What to do
Monitor blood glucose and serum potassium after starting chlorothiazide. Adjust the antidiabetic regimen if glycemic control deteriorates.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorothiazide and Rosiglitazone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Rosiglitazone?
MediHelp rates the interaction as minor. Chlorothiazide and Rosiglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics can raise blood glucose and impair glucose tolerance, which may reduce the effectiveness of rosiglitazone. The effect is generally modest and dose related.
How serious is the interaction between Chlorothiazide and Rosiglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum potassium after starting chlorothiazide. Adjust the antidiabetic regimen if glycemic control deteriorates.
What other medicines interact with Rosiglitazone?
MediHelp also lists interactions of Rosiglitazone with, for example, Insulin aspart protamine / insulin aspart, Insulin aspart-insulin aspart protamine, Insulin aspart. The full list is on the Rosiglitazone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
