Drug interactions
Chlorpheniramine + Clobazam
Severity: Moderate
Chlorpheniramine and Clobazam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a sedating antihistamine with a benzodiazepine increases drowsiness, impaired coordination and, at higher doses, the risk of respiratory depression. Falls and accidents are the main concern, especially in older adults.
What this interaction means in plain words
Chlorpheniramine and Clobazam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpheniramine belongs to Respiratory; Clobazam belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1-antihistamine sedation and benzodiazepine GABA-A enhancement.
What to do
Counsel the patient on additive sedation and avoid alcohol and other depressants. Use a non-sedating antihistamine where possible and monitor for oversedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpheniramine
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Chlorpheniramine with Clobazam?
MediHelp rates the interaction as moderate. Chlorpheniramine and Clobazam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a sedating antihistamine with a benzodiazepine increases drowsiness, impaired coordination and, at higher doses, the risk of respiratory depression. Falls and accidents are the main concern, especially in older adults.
How serious is the interaction between Chlorpheniramine and Clobazam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient on additive sedation and avoid alcohol and other depressants. Use a non-sedating antihistamine where possible and monitor for oversedation.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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