Drug interactions
Chlorpheniramine + Clorazepate
Severity: Moderate
Chlorpheniramine and Clorazepate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpheniramine is a sedating first-generation antihistamine, and with clorazepate it can increase drowsiness and impair concentration and coordination. Older adults may experience confusion and falls.
What this interaction means in plain words
Chlorpheniramine and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpheniramine belongs to Respiratory; Clorazepate belongs to Central Nervous System.
Why it happens
Additive CNS depression from central H1 receptor blockade and benzodiazepine GABA-A potentiation.
What to do
Prefer a non-sedating antihistamine where an antihistamine is required. Counsel about driving and alcohol avoidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Chlorpheniramine with Clorazepate?
MediHelp rates the interaction as moderate. Chlorpheniramine and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpheniramine is a sedating first-generation antihistamine, and with clorazepate it can increase drowsiness and impair concentration and coordination. Older adults may experience confusion and falls.
How serious is the interaction between Chlorpheniramine and Clorazepate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-sedating antihistamine where an antihistamine is required. Counsel about driving and alcohol avoidance.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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