Drug interactions
Chlorpheniramine + Eluxadoline
Severity: Moderate
Chlorpheniramine and Eluxadoline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpheniramine has anticholinergic effects that slow gut motility. With eluxadoline, which is a mu-opioid agonist that also causes constipation, the risk of severe constipation and possibly ileus increases.
What this interaction means in plain words
Chlorpheniramine and Eluxadoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpheniramine belongs to Respiratory; Eluxadoline belongs to Gastrointestinal Tract.
Why it happens
Additive reduction in gastrointestinal motility through anticholinergic and opioid receptor effects.
What to do
Monitor bowel function and stop chlorpheniramine or eluxadoline if severe constipation develops; consider a non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpheniramine
Other interactions of Eluxadoline
Frequently asked questions
Can I take Chlorpheniramine with Eluxadoline?
MediHelp rates the interaction as moderate. Chlorpheniramine and Eluxadoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpheniramine has anticholinergic effects that slow gut motility. With eluxadoline, which is a mu-opioid agonist that also causes constipation, the risk of severe constipation and possibly ileus increases.
How serious is the interaction between Chlorpheniramine and Eluxadoline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function and stop chlorpheniramine or eluxadoline if severe constipation develops; consider a non-sedating antihistamine.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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