Drug interactions
Chlorpheniramine + Etomidate
Severity: Moderate
Chlorpheniramine and Etomidate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpheniramine can add to the hypnotic and sedative effect of etomidate during anesthesia or procedural sedation. Recovery may be slower and patients may be drowsier afterward.
What this interaction means in plain words
Chlorpheniramine and Etomidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpheniramine belongs to Respiratory; Etomidate belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1-antihistamine sedation and GABA-A potentiation by etomidate.
What to do
Titrate etomidate to effect and monitor level of consciousness and respiratory status. Inform the anesthesia team of recent sedating antihistamine use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpheniramine
Other interactions of Etomidate
- Alprazolam + Etomidate Moderate
- Amitriptyline + Etomidate Moderate
- Amobarbital + Etomidate Moderate
- Azelastine + Etomidate Moderate
- Baclofen + Etomidate Moderate
- Brompheniramine + Etomidate Moderate
Frequently asked questions
Can I take Chlorpheniramine with Etomidate?
MediHelp rates the interaction as moderate. Chlorpheniramine and Etomidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpheniramine can add to the hypnotic and sedative effect of etomidate during anesthesia or procedural sedation. Recovery may be slower and patients may be drowsier afterward.
How serious is the interaction between Chlorpheniramine and Etomidate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate etomidate to effect and monitor level of consciousness and respiratory status. Inform the anesthesia team of recent sedating antihistamine use.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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