Drug interactions
Chlorpheniramine + Fluphenazine
Severity: Moderate
Chlorpheniramine and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpheniramine is a sedating first-generation antihistamine with anticholinergic activity, and fluphenazine is also sedating and anticholinergic. Together they can increase drowsiness, impair psychomotor performance and add to anticholinergic effects such as dry mouth, constipation and urinary retention.
What this interaction means in plain words
Chlorpheniramine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpheniramine belongs to Respiratory; Fluphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and additive antihistaminic and anticholinergic effects.
What to do
Warn the patient about drowsiness and avoid driving or operating machinery until the response is known. Consider a non-sedating antihistamine, particularly in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Chlorpheniramine with Fluphenazine?
MediHelp rates the interaction as moderate. Chlorpheniramine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpheniramine is a sedating first-generation antihistamine with anticholinergic activity, and fluphenazine is also sedating and anticholinergic. Together they can increase drowsiness, impair psychomotor performance and add to anticholinergic effects such as dry mouth, constipation and urinary retention.
How serious is the interaction between Chlorpheniramine and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn the patient about drowsiness and avoid driving or operating machinery until the response is known. Consider a non-sedating antihistamine, particularly in older adults.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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