Drug interactions
Chlorpheniramine + Haloperidol
Severity: Moderate
Chlorpheniramine and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpheniramine is a sedating antihistamine with anticholinergic effects, and with haloperidol it can increase drowsiness and impair psychomotor performance. Anticholinergic effects may also add up.
What this interaction means in plain words
Chlorpheniramine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpheniramine belongs to Respiratory; Haloperidol belongs to Central Nervous System.
Why it happens
Additive CNS depression and antimuscarinic effects.
What to do
Warn the patient about sedation and avoid driving until response is known. Use a non-sedating antihistamine where possible, especially in the elderly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Chlorpheniramine with Haloperidol?
MediHelp rates the interaction as moderate. Chlorpheniramine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpheniramine is a sedating antihistamine with anticholinergic effects, and with haloperidol it can increase drowsiness and impair psychomotor performance. Anticholinergic effects may also add up.
How serious is the interaction between Chlorpheniramine and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn the patient about sedation and avoid driving until response is known. Use a non-sedating antihistamine where possible, especially in the elderly.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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