Drug interactions
Chlorpheniramine + Hydromorphone
Severity: Moderate
Chlorpheniramine and Hydromorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpheniramine is a sedating first-generation antihistamine that adds to the drowsiness and psychomotor impairment caused by hydromorphone. The effect is typically manageable but is more pronounced in older adults.
What this interaction means in plain words
Chlorpheniramine and Hydromorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpheniramine belongs to Respiratory; Hydromorphone belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid and sedating antihistamine effects.
What to do
Monitor for excessive sedation and advise against driving or operating machinery. Consider a non-sedating antihistamine if appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Chlorpheniramine with Hydromorphone?
MediHelp rates the interaction as moderate. Chlorpheniramine and Hydromorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpheniramine is a sedating first-generation antihistamine that adds to the drowsiness and psychomotor impairment caused by hydromorphone. The effect is typically manageable but is more pronounced in older adults.
How serious is the interaction between Chlorpheniramine and Hydromorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and advise against driving or operating machinery. Consider a non-sedating antihistamine if appropriate.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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