Drug interactions
Chlorpheniramine + Iloperidone
Severity: Moderate
Chlorpheniramine and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, and iloperidone may also modestly inhibit CYP3A4, potentially raising chlorpheniramine levels. This can intensify drowsiness, dizziness and anticholinergic effects.
What this interaction means in plain words
Chlorpheniramine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpheniramine belongs to Respiratory; Iloperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression plus possible CYP3A4 inhibition by iloperidone reducing chlorpheniramine clearance.
What to do
Monitor for excessive sedation, orthostatic hypotension and anticholinergic effects. Reduce the chlorpheniramine dose or switch to a non-sedating antihistamine if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpheniramine
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Chlorpheniramine with Iloperidone?
MediHelp rates the interaction as moderate. Chlorpheniramine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, and iloperidone may also modestly inhibit CYP3A4, potentially raising chlorpheniramine levels. This can intensify drowsiness, dizziness and anticholinergic effects.
How serious is the interaction between Chlorpheniramine and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, orthostatic hypotension and anticholinergic effects. Reduce the chlorpheniramine dose or switch to a non-sedating antihistamine if needed.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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