Drug interactions
Chlorpheniramine + Lasmiditan
Severity: Moderate
Chlorpheniramine and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan commonly causes dizziness and somnolence, and chlorpheniramine adds to this sedation. Combined use can impair alertness and driving ability.
What this interaction means in plain words
Chlorpheniramine and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpheniramine belongs to Respiratory; Lasmiditan belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects of a 5-HT1F agonist and a sedating H1 antihistamine.
What to do
Counsel patients not to drive or operate machinery for at least 8 hours after lasmiditan. Consider a non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpheniramine
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Chlorpheniramine with Lasmiditan?
MediHelp rates the interaction as moderate. Chlorpheniramine and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan commonly causes dizziness and somnolence, and chlorpheniramine adds to this sedation. Combined use can impair alertness and driving ability.
How serious is the interaction between Chlorpheniramine and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients not to drive or operate machinery for at least 8 hours after lasmiditan. Consider a non-sedating antihistamine.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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