Drug interactions
Chlorpheniramine + Paliperidone
Severity: Moderate
Chlorpheniramine and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpheniramine is a sedating antihistamine, and with paliperidone it can increase drowsiness, impair psychomotor performance and add to anticholinergic effects.
What this interaction means in plain words
Chlorpheniramine and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpheniramine belongs to Respiratory; Paliperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression and antimuscarinic effects.
What to do
Warn patients about sedation and avoid driving until response is known. Choose a non-sedating antihistamine where possible, especially in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Chlorpheniramine with Paliperidone?
MediHelp rates the interaction as moderate. Chlorpheniramine and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpheniramine is a sedating antihistamine, and with paliperidone it can increase drowsiness, impair psychomotor performance and add to anticholinergic effects.
How serious is the interaction between Chlorpheniramine and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about sedation and avoid driving until response is known. Choose a non-sedating antihistamine where possible, especially in older adults.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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