Drug interactions
Chlorpheniramine + Pentazocine
Severity: Moderate
Chlorpheniramine and Pentazocine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpheniramine is a sedating first-generation antihistamine, and combining it with pentazocine can increase drowsiness and impair psychomotor performance. Anticholinergic effects may also be additive.
What this interaction means in plain words
Chlorpheniramine and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpheniramine belongs to Respiratory; Pentazocine belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid activity and H1 antihistamine effects.
What to do
Advise patients to avoid driving and alcohol, and use the lowest effective doses. Consider a non-sedating antihistamine instead.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pentazocine
- Calcium / magnesium / potassium / sodium oxybates + Pentazocine Contraindicated
- Olanzapine / samidorphan + Pentazocine Contraindicated
- Pentazocine + Phenelzine Contraindicated
- Pentazocine + Tranylcypromine Contraindicated
- Alfentanil + Pentazocine Major
- Alprazolam + Pentazocine Major
Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Chlorpheniramine with Pentazocine?
MediHelp rates the interaction as moderate. Chlorpheniramine and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpheniramine is a sedating first-generation antihistamine, and combining it with pentazocine can increase drowsiness and impair psychomotor performance. Anticholinergic effects may also be additive.
How serious is the interaction between Chlorpheniramine and Pentazocine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid driving and alcohol, and use the lowest effective doses. Consider a non-sedating antihistamine instead.
What other medicines interact with Pentazocine?
MediHelp also lists interactions of Pentazocine with, for example, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan, Phenelzine. The full list is on the Pentazocine page.
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