Drug interactions
Chlorpheniramine + Perphenazine
Severity: Moderate
Chlorpheniramine and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and have anticholinergic activity, so combined use can lead to marked drowsiness, dry mouth, urinary retention and confusion. Chlorpheniramine may also modestly raise perphenazine exposure through CYP2D6 inhibition.
What this interaction means in plain words
Chlorpheniramine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpheniramine belongs to Respiratory; Perphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and anticholinergic effects; possible CYP2D6 inhibition by chlorpheniramine.
What to do
Warn about drowsiness and avoid driving or alcohol. Monitor older adults for anticholinergic toxicity, or choose a non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Chlorpheniramine with Perphenazine?
MediHelp rates the interaction as moderate. Chlorpheniramine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and have anticholinergic activity, so combined use can lead to marked drowsiness, dry mouth, urinary retention and confusion. Chlorpheniramine may also modestly raise perphenazine exposure through CYP2D6 inhibition.
How serious is the interaction between Chlorpheniramine and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn about drowsiness and avoid driving or alcohol. Monitor older adults for anticholinergic toxicity, or choose a non-sedating antihistamine.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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