Drug interactions
Chlorpromazine + Clemastine
Severity: Moderate
Chlorpromazine and Clemastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clemastine is a sedating, anticholinergic antihistamine. With chlorpromazine it may produce additive drowsiness and anticholinergic effects including dry mouth, blurred vision, constipation and urinary retention.
What this interaction means in plain words
Chlorpromazine and Clemastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Clemastine belongs to Respiratory.
Why it happens
Additive H1 blockade, CNS depression and muscarinic antagonism.
What to do
Use a non-sedating antihistamine if possible. Counsel on avoiding driving and monitor older patients for confusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Clemastine
Frequently asked questions
Can I take Chlorpromazine with Clemastine?
MediHelp rates the interaction as moderate. Chlorpromazine and Clemastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clemastine is a sedating, anticholinergic antihistamine. With chlorpromazine it may produce additive drowsiness and anticholinergic effects including dry mouth, blurred vision, constipation and urinary retention.
How serious is the interaction between Chlorpromazine and Clemastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-sedating antihistamine if possible. Counsel on avoiding driving and monitor older patients for confusion.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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