Drug interactions
Chlorpromazine + Dabrafenib
Severity: Moderate
Chlorpromazine and Dabrafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so giving them together may add to the risk of torsades de pointes and other ventricular arrhythmias. Risk is higher with electrolyte disturbances, bradycardia or existing cardiac disease.
What this interaction means in plain words
Chlorpromazine and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Dabrafenib belongs to Oncology.
Why it happens
Additive QT prolongation through pharmacodynamic effects on cardiac repolarization; dabrafenib may also induce CYP3A4 and lower chlorpromazine exposure to a minor degree.
What to do
Obtain a baseline ECG and repeat it after starting or changing doses, and correct potassium and magnesium abnormalities. Consider an alternative if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Dabrafenib
Frequently asked questions
Can I take Chlorpromazine with Dabrafenib?
MediHelp rates the interaction as moderate. Chlorpromazine and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so giving them together may add to the risk of torsades de pointes and other ventricular arrhythmias. Risk is higher with electrolyte disturbances, bradycardia or existing cardiac disease.
How serious is the interaction between Chlorpromazine and Dabrafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat it after starting or changing doses, and correct potassium and magnesium abnormalities. Consider an alternative if the QTc becomes markedly prolonged.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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