Drug interactions
Chlorpromazine + Darifenacin
Severity: Moderate
Chlorpromazine and Darifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine has substantial anticholinergic activity that adds to darifenacin, increasing dry mouth, constipation, urinary retention, blurred vision and confusion. Darifenacin may also modestly raise chlorpromazine levels via CYP2D6 inhibition.
What this interaction means in plain words
Chlorpromazine and Darifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Darifenacin belongs to Genitourinary.
Why it happens
Additive antimuscarinic effects with possible CYP2D6 inhibition by darifenacin.
What to do
Monitor for anticholinergic toxicity and sedation or hypotension from chlorpromazine. Reduce doses or choose alternatives in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Darifenacin?
MediHelp rates the interaction as moderate. Chlorpromazine and Darifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine has substantial anticholinergic activity that adds to darifenacin, increasing dry mouth, constipation, urinary retention, blurred vision and confusion. Darifenacin may also modestly raise chlorpromazine levels via CYP2D6 inhibition.
How serious is the interaction between Chlorpromazine and Darifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and sedation or hypotension from chlorpromazine. Reduce doses or choose alternatives in elderly patients.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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