Drug interactions
Chlorpromazine + Dexfenfluramine
Severity: Minor
Chlorpromazine and Dexfenfluramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexfenfluramine is a serotonergic anorectic and chlorpromazine a dopamine-blocking antipsychotic with QT liability. Opposing effects on alertness are possible and a clinically meaningful interaction is poorly documented.
What this interaction means in plain words
Chlorpromazine and Dexfenfluramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mechanism not well established; possible opposing CNS effects and a theoretical additive effect on cardiac repolarization.
What to do
No specific action beyond awareness; consider an ECG if other QT risk factors are present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Dexfenfluramine?
MediHelp rates the interaction as minor. Chlorpromazine and Dexfenfluramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexfenfluramine is a serotonergic anorectic and chlorpromazine a dopamine-blocking antipsychotic with QT liability. Opposing effects on alertness are possible and a clinically meaningful interaction is poorly documented.
How serious is the interaction between Chlorpromazine and Dexfenfluramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action beyond awareness; consider an ECG if other QT risk factors are present.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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