Drug interactions
Chlorpromazine + Dextroamphetamine
Severity: Moderate
Chlorpromazine and Dextroamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine blocks dopamine receptors and can reduce the stimulant and anorectic effects of amphetamines, while amphetamines may worsen psychosis. Both drugs can affect heart rate and rhythm, and chlorpromazine prolongs the QT interval.
What this interaction means in plain words
Chlorpromazine and Dextroamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Dextroamphetamine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism via dopamine receptor blockade, with additive cardiovascular effects.
What to do
Monitor therapeutic response, mental status and heart rate, and obtain an ECG in patients with cardiac risk factors. Avoid use in patients with psychosis unless closely supervised.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Dextroamphetamine?
MediHelp rates the interaction as moderate. Chlorpromazine and Dextroamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine blocks dopamine receptors and can reduce the stimulant and anorectic effects of amphetamines, while amphetamines may worsen psychosis. Both drugs can affect heart rate and rhythm, and chlorpromazine prolongs the QT interval.
How serious is the interaction between Chlorpromazine and Dextroamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor therapeutic response, mental status and heart rate, and obtain an ECG in patients with cardiac risk factors. Avoid use in patients with psychosis unless closely supervised.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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