Drug interactions
Chlorpromazine + Diethylpropion
Severity: Moderate
Chlorpromazine and Diethylpropion: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diethylpropion is a sympathomimetic stimulant and chlorpromazine a sedating antipsychotic, so they may counteract each other's effects. Antipsychotics can reduce the anorectic action, and stimulants may worsen psychotic symptoms.
What this interaction means in plain words
Chlorpromazine and Diethylpropion can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic opposition between dopamine blockade and sympathomimetic catecholamine release.
What to do
Monitor mental state, blood pressure and heart rate, and reassess the need for the anorectic in patients with psychiatric illness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Diethylpropion?
MediHelp rates the interaction as moderate. Chlorpromazine and Diethylpropion can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diethylpropion is a sympathomimetic stimulant and chlorpromazine a sedating antipsychotic, so they may counteract each other's effects. Antipsychotics can reduce the anorectic action, and stimulants may worsen psychotic symptoms.
How serious is the interaction between Chlorpromazine and Diethylpropion?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor mental state, blood pressure and heart rate, and reassess the need for the anorectic in patients with psychiatric illness.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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