Drug interactions
Chlorpromazine + Difenoxin
Severity: Moderate
Chlorpromazine and Difenoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difenoxin is an opioid antidiarrheal metabolite of diphenoxylate and can cause CNS depression at higher exposures. Added to chlorpromazine it may increase sedation, and anticholinergic effects may add to gastrointestinal slowing.
What this interaction means in plain words
Chlorpromazine and Difenoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Difenoxin belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression and additive anticholinergic effects.
What to do
Use the lowest effective dose of difenoxin and watch for excess sedation, constipation or ileus. Avoid alcohol and other depressants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Difenoxin
Frequently asked questions
Can I take Chlorpromazine with Difenoxin?
MediHelp rates the interaction as moderate. Chlorpromazine and Difenoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difenoxin is an opioid antidiarrheal metabolite of diphenoxylate and can cause CNS depression at higher exposures. Added to chlorpromazine it may increase sedation, and anticholinergic effects may add to gastrointestinal slowing.
How serious is the interaction between Chlorpromazine and Difenoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dose of difenoxin and watch for excess sedation, constipation or ileus. Avoid alcohol and other depressants.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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