Drug interactions
Chlorpromazine + Dipipanone
Severity: Major
Chlorpromazine and Dipipanone: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dipipanone is a strong opioid, and combining it with chlorpromazine increases sedation, hypotension and the risk of respiratory depression. Severe outcomes include coma and death.
What this interaction means in plain words
Chlorpromazine and Dipipanone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression via opioid agonism and phenothiazine sedation.
What to do
Reduce initial doses and titrate to effect while monitoring sedation, respiratory rate and blood pressure. Avoid in patients with respiratory compromise.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Dipipanone?
MediHelp rates the interaction as major. Chlorpromazine and Dipipanone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dipipanone is a strong opioid, and combining it with chlorpromazine increases sedation, hypotension and the risk of respiratory depression. Severe outcomes include coma and death.
How serious is the interaction between Chlorpromazine and Dipipanone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce initial doses and titrate to effect while monitoring sedation, respiratory rate and blood pressure. Avoid in patients with respiratory compromise.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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