Drug interactions
Chlorpromazine + Donepezil transdermal
Severity: Moderate
Chlorpromazine and Donepezil transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine has anticholinergic properties that oppose the cholinesterase inhibition of donepezil, which can reduce cognitive benefit. Donepezil may also worsen extrapyramidal symptoms with antipsychotics.
What this interaction means in plain words
Chlorpromazine and Donepezil transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism between antimuscarinic activity and cholinesterase inhibition.
What to do
Avoid or minimize anticholinergic antipsychotics in dementia where possible. Monitor cognition and extrapyramidal symptoms, and prefer a less anticholinergic agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Donepezil transdermal?
MediHelp rates the interaction as moderate. Chlorpromazine and Donepezil transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine has anticholinergic properties that oppose the cholinesterase inhibition of donepezil, which can reduce cognitive benefit. Donepezil may also worsen extrapyramidal symptoms with antipsychotics.
How serious is the interaction between Chlorpromazine and Donepezil transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid or minimize anticholinergic antipsychotics in dementia where possible. Monitor cognition and extrapyramidal symptoms, and prefer a less anticholinergic agent.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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