Drug interactions
Chlorpromazine + Enalapril
Severity: Moderate
Chlorpromazine and Enalapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine blocks alpha-adrenergic receptors and can cause orthostatic hypotension. With enalapril the hypotensive effect may be additive, increasing the risk of dizziness and falls.
What this interaction means in plain words
Chlorpromazine and Enalapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Enalapril belongs to Cardiovascular.
Why it happens
Additive hypotension from phenothiazine alpha-1 blockade and ACE inhibition.
What to do
Monitor blood pressure and orthostatic symptoms, especially at initiation and dose increases. Reduce doses if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Enalapril?
MediHelp rates the interaction as moderate. Chlorpromazine and Enalapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine blocks alpha-adrenergic receptors and can cause orthostatic hypotension. With enalapril the hypotensive effect may be additive, increasing the risk of dizziness and falls.
How serious is the interaction between Chlorpromazine and Enalapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, especially at initiation and dose increases. Reduce doses if symptomatic hypotension develops.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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