Drug interactions
Chlorpromazine + Epinephrine racemic
Severity: Moderate
Chlorpromazine and Epinephrine racemic: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine blocks alpha-adrenergic receptors, so epinephrine's beta-mediated vasodilation may be unopposed, causing hypotension and tachycardia. Epinephrine and chlorpromazine can both also affect cardiac repolarization and arrhythmia risk.
What this interaction means in plain words
Chlorpromazine and Epinephrine racemic can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Alpha-adrenergic blockade by chlorpromazine reverses the pressor response of epinephrine, with possible additive arrhythmogenic effects.
What to do
Monitor blood pressure and heart rhythm. If hypotension occurs, use a pure alpha agonist such as norepinephrine or phenylephrine rather than more epinephrine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Epinephrine racemic?
MediHelp rates the interaction as moderate. Chlorpromazine and Epinephrine racemic can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine blocks alpha-adrenergic receptors, so epinephrine's beta-mediated vasodilation may be unopposed, causing hypotension and tachycardia. Epinephrine and chlorpromazine can both also affect cardiac repolarization and arrhythmia risk.
How serious is the interaction between Chlorpromazine and Epinephrine racemic?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rhythm. If hypotension occurs, use a pure alpha agonist such as norepinephrine or phenylephrine rather than more epinephrine.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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