Drug interactions
Chlorpromazine + Esketamine intranasal
Severity: Moderate
Chlorpromazine and Esketamine intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause sedation and dissociation, and combined use may increase drowsiness and impaired alertness. Blood pressure changes may also be additive.
What this interaction means in plain words
Chlorpromazine and Esketamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects.
What to do
Monitor sedation and blood pressure during and after esketamine administration and observe for the full post-dose period. Counsel against driving until the next day.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Esketamine intranasal?
MediHelp rates the interaction as moderate. Chlorpromazine and Esketamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause sedation and dissociation, and combined use may increase drowsiness and impaired alertness. Blood pressure changes may also be additive.
How serious is the interaction between Chlorpromazine and Esketamine intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure during and after esketamine administration and observe for the full post-dose period. Counsel against driving until the next day.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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