Drug interactions
Chlorpromazine + Gemtuzumab
Severity: Moderate
Chlorpromazine and Gemtuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine and gemtuzumab ozogamicin have each been associated with QTc prolongation. Used together, they may increase the risk of ventricular arrhythmias including torsades de pointes, particularly with electrolyte disturbances.
What this interaction means in plain words
Chlorpromazine and Gemtuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive prolongation of cardiac repolarization (QTc) through pharmacodynamic effects.
What to do
Obtain a baseline ECG and monitor QTc during treatment, and correct potassium and magnesium abnormalities. Consider an alternative to chlorpromazine if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Gemtuzumab?
MediHelp rates the interaction as moderate. Chlorpromazine and Gemtuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine and gemtuzumab ozogamicin have each been associated with QTc prolongation. Used together, they may increase the risk of ventricular arrhythmias including torsades de pointes, particularly with electrolyte disturbances.
How serious is the interaction between Chlorpromazine and Gemtuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc during treatment, and correct potassium and magnesium abnormalities. Consider an alternative to chlorpromazine if the QTc becomes markedly prolonged.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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