Drug interactions
Chlorpromazine + Glycopyrronium tosylate
Severity: Moderate
Chlorpromazine and Glycopyrronium tosylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topical glycopyrronium tosylate is applied to the axillae for hyperhidrosis and can be absorbed enough to cause systemic anticholinergic effects. Chlorpromazine may add to these effects, producing dry mouth, urinary hesitancy, blurred vision or constipation.
What this interaction means in plain words
Chlorpromazine and Glycopyrronium tosylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic effects such as urinary retention, constipation and blurred vision. Stop the topical product if significant symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Glycopyrronium tosylate?
MediHelp rates the interaction as moderate. Chlorpromazine and Glycopyrronium tosylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Topical glycopyrronium tosylate is applied to the axillae for hyperhidrosis and can be absorbed enough to cause systemic anticholinergic effects. Chlorpromazine may add to these effects, producing dry mouth, urinary hesitancy, blurred vision or constipation.
How serious is the interaction between Chlorpromazine and Glycopyrronium tosylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects such as urinary retention, constipation and blurred vision. Stop the topical product if significant symptoms develop.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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