Drug interactions
Chlorpromazine + Henbane
Severity: Moderate
Chlorpromazine and Henbane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Henbane contains the antimuscarinic alkaloids hyoscyamine and scopolamine, which add to the anticholinergic burden of chlorpromazine. This can cause confusion, constipation, urinary retention, tachycardia and heat intolerance.
What this interaction means in plain words
Chlorpromazine and Henbane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects; reduced gastric motility may also slightly alter oral absorption of chlorpromazine.
What to do
Avoid combining where possible, and monitor for anticholinergic toxicity, especially in older adults. Reduce the dose or stop the henbane preparation if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorpromazine and Henbane, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Henbane?
MediHelp rates the interaction as moderate. Chlorpromazine and Henbane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Henbane contains the antimuscarinic alkaloids hyoscyamine and scopolamine, which add to the anticholinergic burden of chlorpromazine. This can cause confusion, constipation, urinary retention, tachycardia and heat intolerance.
How serious is the interaction between Chlorpromazine and Henbane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, and monitor for anticholinergic toxicity, especially in older adults. Reduce the dose or stop the henbane preparation if symptoms occur.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
