Drug interactions
Chlorpromazine + Hyoscyamine spray
Severity: Moderate
Chlorpromazine and Hyoscyamine spray: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hyoscyamine given as an oromucosal spray is absorbed systemically and adds to the anticholinergic effects of chlorpromazine. This may cause dry mouth, constipation, urinary retention, confusion and tachycardia.
What this interaction means in plain words
Chlorpromazine and Hyoscyamine spray can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic adverse effects, particularly in older patients. Lower the dose or choose an alternative if symptoms become bothersome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Hyoscyamine spray?
MediHelp rates the interaction as moderate. Chlorpromazine and Hyoscyamine spray can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hyoscyamine given as an oromucosal spray is absorbed systemically and adds to the anticholinergic effects of chlorpromazine. This may cause dry mouth, constipation, urinary retention, confusion and tachycardia.
How serious is the interaction between Chlorpromazine and Hyoscyamine spray?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects, particularly in older patients. Lower the dose or choose an alternative if symptoms become bothersome.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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