Drug interactions
Chlorpromazine + Insulin degludec / insulin aspart
Severity: Moderate
Chlorpromazine and Insulin degludec / insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines such as chlorpromazine can raise blood glucose and may reduce the glucose-lowering effect of insulin. Patients with diabetes may need more insulin.
What this interaction means in plain words
Chlorpromazine and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chlorpromazine may impair glucose tolerance and insulin sensitivity, opposing insulin action.
What to do
Monitor blood glucose more frequently when starting, stopping or changing the chlorpromazine dose. Adjust insulin doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Insulin degludec / insulin aspart?
MediHelp rates the interaction as moderate. Chlorpromazine and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazines such as chlorpromazine can raise blood glucose and may reduce the glucose-lowering effect of insulin. Patients with diabetes may need more insulin.
How serious is the interaction between Chlorpromazine and Insulin degludec / insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting, stopping or changing the chlorpromazine dose. Adjust insulin doses as needed.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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