Drug interactions
Chlorpromazine + Lisuride
Severity: Major
Chlorpromazine and Lisuride: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lisuride is a dopamine agonist and chlorpromazine blocks dopamine receptors. They oppose each other, so the effect of lisuride on parkinsonism or prolactin is reduced and extrapyramidal symptoms may worsen.
What this interaction means in plain words
Chlorpromazine and Lisuride can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic antagonism at dopamine D2 receptors.
What to do
Avoid the combination. If an antipsychotic is needed in a patient with Parkinson disease, use one with minimal D2 blockade such as quetiapine or clozapine.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorpromazine and Lisuride, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Lisuride?
MediHelp rates the interaction as major. Chlorpromazine and Lisuride can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lisuride is a dopamine agonist and chlorpromazine blocks dopamine receptors. They oppose each other, so the effect of lisuride on parkinsonism or prolactin is reduced and extrapyramidal symptoms may worsen.
How serious is the interaction between Chlorpromazine and Lisuride?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If an antipsychotic is needed in a patient with Parkinson disease, use one with minimal D2 blockade such as quetiapine or clozapine.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
