Drug interactions
Chlorpromazine + Loprazolam
Severity: Moderate
Chlorpromazine and Loprazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents depress the CNS, so together they can cause marked drowsiness, impaired coordination and reduced alertness. The risk is higher in older people and with higher doses.
What this interaction means in plain words
Chlorpromazine and Loprazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression (GABA-A potentiation by the benzodiazepine plus antihistaminic and antidopaminergic sedation).
What to do
Use the lowest effective doses and monitor for oversedation and falls. Advise patients to avoid alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Loprazolam?
MediHelp rates the interaction as moderate. Chlorpromazine and Loprazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents depress the CNS, so together they can cause marked drowsiness, impaired coordination and reduced alertness. The risk is higher in older people and with higher doses.
How serious is the interaction between Chlorpromazine and Loprazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation and falls. Advise patients to avoid alcohol and driving.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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