Drug interactions
Chlorpromazine + Lorcaserin
Severity: Moderate
Chlorpromazine and Lorcaserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorcaserin inhibits CYP2D6, which contributes to chlorpromazine metabolism, so chlorpromazine exposure may rise. Both drugs also affect serotonergic and CNS pathways, so adverse effects such as sedation or extrapyramidal symptoms may be more frequent.
What this interaction means in plain words
Chlorpromazine and Lorcaserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP2D6 by lorcaserin reduces chlorpromazine clearance.
What to do
Monitor for increased chlorpromazine effects such as sedation, hypotension and extrapyramidal symptoms. Reduce the chlorpromazine dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Lorcaserin?
MediHelp rates the interaction as moderate. Chlorpromazine and Lorcaserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorcaserin inhibits CYP2D6, which contributes to chlorpromazine metabolism, so chlorpromazine exposure may rise. Both drugs also affect serotonergic and CNS pathways, so adverse effects such as sedation or extrapyramidal symptoms may be more frequent.
How serious is the interaction between Chlorpromazine and Lorcaserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased chlorpromazine effects such as sedation, hypotension and extrapyramidal symptoms. Reduce the chlorpromazine dose if adverse effects appear.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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