Drug interactions
Chlorpromazine + Loxapine inhaled
Severity: Moderate
Chlorpromazine and Loxapine inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are dopamine-blocking antipsychotics, so combining them adds to sedation, extrapyramidal symptoms and the risk of neuroleptic malignant syndrome. Inhaled loxapine also carries a risk of bronchospasm, and sedation may add to that of chlorpromazine.
What this interaction means in plain words
Chlorpromazine and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive dopamine D2 receptor antagonism and CNS depression.
What to do
Monitor for sedation, extrapyramidal symptoms, and signs of neuroleptic malignant syndrome such as fever and rigidity. Observe the patient for bronchospasm after inhalation and avoid unnecessary additional antipsychotic dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorpromazine and Loxapine inhaled, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Loxapine inhaled?
MediHelp rates the interaction as moderate. Chlorpromazine and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are dopamine-blocking antipsychotics, so combining them adds to sedation, extrapyramidal symptoms and the risk of neuroleptic malignant syndrome. Inhaled loxapine also carries a risk of bronchospasm, and sedation may add to that of chlorpromazine.
How serious is the interaction between Chlorpromazine and Loxapine inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, extrapyramidal symptoms, and signs of neuroleptic malignant syndrome such as fever and rigidity. Observe the patient for bronchospasm after inhalation and avoid unnecessary additional antipsychotic dosing.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
