Drug interactions
Chlorpromazine + Lumefantrine
Severity: Major
Chlorpromazine and Lumefantrine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine, given as artemether-lumefantrine, can prolong the QT interval, and chlorpromazine shares this effect. Together they increase the risk of torsade de pointes.
What this interaction means in plain words
Chlorpromazine and Lumefantrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation through effects on cardiac repolarization.
What to do
Avoid if possible or use an alternative antimalarial. If unavoidable, obtain an ECG and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Lumefantrine?
MediHelp rates the interaction as major. Chlorpromazine and Lumefantrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lumefantrine, given as artemether-lumefantrine, can prolong the QT interval, and chlorpromazine shares this effect. Together they increase the risk of torsade de pointes.
How serious is the interaction between Chlorpromazine and Lumefantrine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible or use an alternative antimalarial. If unavoidable, obtain an ECG and correct potassium and magnesium.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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