Drug interactions
Chlorpromazine + Meclizine
Severity: Moderate
Chlorpromazine and Meclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclizine is an anticholinergic antihistamine and chlorpromazine has strong anticholinergic and sedative properties, so the combination can cause marked drowsiness, dry mouth, urinary retention, constipation and confusion. Older adults are particularly vulnerable.
What this interaction means in plain words
Chlorpromazine and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Meclizine belongs to Respiratory.
Why it happens
Additive antimuscarinic and H1-antihistamine central nervous system depressant effects.
What to do
Monitor for anticholinergic toxicity and oversedation, particularly in elderly patients, and reduce the dose or choose a non-sedating alternative if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Meclizine
Frequently asked questions
Can I take Chlorpromazine with Meclizine?
MediHelp rates the interaction as moderate. Chlorpromazine and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclizine is an anticholinergic antihistamine and chlorpromazine has strong anticholinergic and sedative properties, so the combination can cause marked drowsiness, dry mouth, urinary retention, constipation and confusion. Older adults are particularly vulnerable.
How serious is the interaction between Chlorpromazine and Meclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and oversedation, particularly in elderly patients, and reduce the dose or choose a non-sedating alternative if these occur.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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