Drug interactions
Chlorpromazine + Metaproterenol
Severity: Minor
Chlorpromazine and Metaproterenol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine blocks alpha-adrenergic receptors and can cause vasodilation and hypotension. Metaproterenol, a beta2 agonist, can also lower diastolic pressure and cause tachycardia, and both drugs can affect cardiac rhythm, so the combination may add to cardiovascular effects. The clinical significance is generally modest.
What this interaction means in plain words
Chlorpromazine and Metaproterenol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive cardiovascular effects (vasodilation, tachycardia, QT effects); no well-defined pharmacokinetic mechanism.
What to do
Monitor heart rate and blood pressure when starting or increasing doses. Be more cautious in patients with QT risk factors or cardiac disease.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Metaproterenol?
MediHelp rates the interaction as minor. Chlorpromazine and Metaproterenol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chlorpromazine blocks alpha-adrenergic receptors and can cause vasodilation and hypotension. Metaproterenol, a beta2 agonist, can also lower diastolic pressure and cause tachycardia, and both drugs can affect cardiac rhythm, so the combination may add to cardiovascular effects. The clinical significance is generally modest.
How serious is the interaction between Chlorpromazine and Metaproterenol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting or increasing doses. Be more cautious in patients with QT risk factors or cardiac disease.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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