Drug interactions
Chlorpromazine + Metformin-sitagliptin
Severity: Moderate
Chlorpromazine and Metformin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine can raise blood glucose and impair glycemic control in patients taking antidiabetic drugs. Stopping the phenothiazine may later unmask hypoglycemia if the antidiabetic doses were increased.
What this interaction means in plain words
Chlorpromazine and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: phenothiazines can reduce insulin secretion and cause insulin resistance.
What to do
Monitor blood glucose when starting, changing or stopping chlorpromazine. Adjust antidiabetic doses accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Metformin-sitagliptin?
MediHelp rates the interaction as moderate. Chlorpromazine and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine can raise blood glucose and impair glycemic control in patients taking antidiabetic drugs. Stopping the phenothiazine may later unmask hypoglycemia if the antidiabetic doses were increased.
How serious is the interaction between Chlorpromazine and Metformin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting, changing or stopping chlorpromazine. Adjust antidiabetic doses accordingly.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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