Drug interactions
Chlorpromazine + Methscopolamine
Severity: Moderate
Chlorpromazine and Methscopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have anticholinergic activity, so together they may cause dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion, particularly in older adults. Anticholinergics may also slow gut motility and could modestly reduce chlorpromazine absorption.
What this interaction means in plain words
Chlorpromazine and Methscopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects, with possible reduced oral absorption of chlorpromazine through slowed gastrointestinal motility.
What to do
Monitor for anticholinergic toxicity such as retention, constipation and delirium, and for loss of antipsychotic effect. Reduce or avoid the combination in elderly patients or those with glaucoma or obstruction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorpromazine and Methscopolamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Methscopolamine?
MediHelp rates the interaction as moderate. Chlorpromazine and Methscopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have anticholinergic activity, so together they may cause dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion, particularly in older adults. Anticholinergics may also slow gut motility and could modestly reduce chlorpromazine absorption.
How serious is the interaction between Chlorpromazine and Methscopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity such as retention, constipation and delirium, and for loss of antipsychotic effect. Reduce or avoid the combination in elderly patients or those with glaucoma or obstruction.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
