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Drug interactions

Chlorpromazine + Methyl aminolevulinate

Severity: Moderate

Chlorpromazine and Methyl aminolevulinate: moderate interaction.

Last updated

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Chlorpromazine is a phototoxic drug and methyl aminolevulinate is a topical photosensitizer used with light therapy. Together they may increase the skin's reaction to light, with more intense erythema or burning.

What this interaction means in plain words

Chlorpromazine and Methyl aminolevulinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Evidence level: Low

Why it happens

Additive photosensitization of the skin.

What to do

Counsel on strict sun protection and watch the treated area for exaggerated phototoxic reactions. Consider delaying photodynamic therapy if a safe interruption of chlorpromazine is possible.

What to ask your pharmacist

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Frequently asked questions

Can I take Chlorpromazine with Methyl aminolevulinate?

MediHelp rates the interaction as moderate. Chlorpromazine and Methyl aminolevulinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine is a phototoxic drug and methyl aminolevulinate is a topical photosensitizer used with light therapy. Together they may increase the skin's reaction to light, with more intense erythema or burning.

How serious is the interaction between Chlorpromazine and Methyl aminolevulinate?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on strict sun protection and watch the treated area for exaggerated phototoxic reactions. Consider delaying photodynamic therapy if a safe interruption of chlorpromazine is possible.

What other medicines interact with Chlorpromazine?

MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.

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