Drug interactions
Chlorpromazine + Methylenedioxymethamphetamine
Severity: Major
Chlorpromazine and Methylenedioxymethamphetamine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MDMA is a stimulant that raises heart rate, blood pressure and temperature, while chlorpromazine prolongs the QT interval and impairs thermoregulation. The combination may raise the risk of arrhythmia and hyperthermia, and the two have opposing effects on alertness. Data in humans are limited.
What this interaction means in plain words
Chlorpromazine and Methylenedioxymethamphetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic opposition and additive cardiac effects (QT prolongation with sympathomimetic stimulation); MDMA also inhibits CYP2D6, which may raise chlorpromazine levels.
What to do
Advise patients to avoid MDMA. If exposure occurs, assess ECG, temperature and electrolytes and monitor for arrhythmia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Methylenedioxymethamphetamine?
MediHelp rates the interaction as major. Chlorpromazine and Methylenedioxymethamphetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. MDMA is a stimulant that raises heart rate, blood pressure and temperature, while chlorpromazine prolongs the QT interval and impairs thermoregulation. The combination may raise the risk of arrhythmia and hyperthermia, and the two have opposing effects on alertness. Data in humans are limited.
How serious is the interaction between Chlorpromazine and Methylenedioxymethamphetamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid MDMA. If exposure occurs, assess ECG, temperature and electrolytes and monitor for arrhythmia.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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